Pre-eclampsia: the role of vascular endothelial growth factor and its interaction with the vascular endothelium

Brockelsby, Jeremy Charles (2001) Pre-eclampsia: the role of vascular endothelial growth factor and its interaction with the vascular endothelium. PhD thesis, University of Nottingham.

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Abstract

Hypothesis:

This thesis set out to test the hypothesis first proposed by Baker et al (1995) that Vascular Endothelial Growth Factor (VEGF) may be involved in the alteration in endothelial function that is observed in the disease of pre-eclampsia.

Aims:

To investigate concentrations of VEGF in plasma from non-pregnant, and normal pregnant women and women with pre-eclampsia.

To investigate uterine and placental expression of VEGF in non-pregnant, normal pregnant women and women with pre-eclampsia.

To investigate some of the vascular adaptations that occur in pregnancy and pre-eclampsia within the uterine and systemic circulations.

To investigate the effect of plasma from women with PE and VEGF on

i) An in vitro endothelial cell culture model.

ii) An in vitro isolated vessel model.

To characterise the mechanism whereby VEGF causes any alteration in vascular function.

Item Type:Thesis (PhD)
Supervisors:Johnson, I.R.
Uncontrolled Keywords:Pre-eclampsia, Vascular endothelial growth factor, Endothelial function in pregnancy, Vascular function in pregnancy, Pregnancy complications
Faculties/Schools:UK Campuses > Faculty of Medicine and Health Sciences > School of Clinical Sciences
ID Code:1836
Deposited By:Mrs K.J. Blore
Deposited On:25 Feb 2011 11:30
Last Modified:25 Feb 2011 11:30

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